Researchers from the Graduate School, Universitas Padjadjaran, led by Theresia Chandra Tania Novy, have conducted a comprehensive systematic review exploring the therapeutic potential of chitosan nanoparticles (NPs) for treating knee osteoarthritis (OA). Their analysis reveals that chitosan NPs—designed to overcome the poor solubility and limited tissue penetration of conventional formulations—demonstrate enhanced bioavailability, sustained drug release, and targeted cartilage delivery. In both preclinical in vitro and in vivo models, these nanoparticles supported cartilage regeneration, suppressed inflammation, and preserved joint integrity, marking a significant advancement over standard chitosan treatments.

These findings carry important implications for several United Nations Sustainable Development Goals (SDGs):

SDG 3 (Good Health and Well-Being) — by offering a novel approach to mitigate osteoarthritis—one of the leading causes of disability worldwide—through targeted therapeutic delivery.

SDG 9 (Industry, Innovation, and Infrastructure) — by employing cutting-edge nanotechnology to innovate drug delivery systems with scope for wider biomedical applications.

SDG 12 (Responsible Consumption and Production) — by advancing a sustainable, biodegradable approach—chitosan being derived from natural sources—in contrast to synthetic alternatives, promoting safer medical treatments with reduced environmental impact.