Unpad Researchers Scale Up Biocompatible PDMS Synthesis for Improved Eye Treatments
Widy
UNPAD Staff Writer




Researcher from the Doctoral Program in Biotechnology, Graduate School, Universitas Padjadjaran—Diba Grace Auliya—has successfully scaled up the production of polydimethylsiloxane (PDMS), a vital polymer used as a substitute for vitreous humour in eye surgeries, particularly for treating retinal detachment. Through ring-opening polymerization of D4 monomer with hexamethyldisiloxane as a chain terminator, the team achieved PDMS synthesis at three- and five-times larger volumes than traditional lab-scale. The material maintained essential optical and mechanical properties—viscosity ranging from ~1,000 to ~4,320 mPa·s, refractive indices between 1.3982 and 1.4008, and surface tension of 20–21 mN/m—with structural integrity confirmed by FTIR, demonstrating parity with commercial PDMS.
By enabling bulk production of high-quality PDMS within Indonesia, this advancement significantly supports several Sustainable Development Goals (SDGs):
SDG 3 (Good Health and Well-Being) — by improving access to essential biomaterials for ocular surgery, potentially reducing treatment costs and expanding patient access.
SDG 9 (Industry, Innovation and Infrastructure) — through technological innovation that builds domestic capacity in biomedical polymer manufacturing.
SDG 12 (Responsible Consumption and Production) — by producing locally, reducing reliance on costly imports, and establishing scalable, sustainable production systems.
https://www.tandfonline.com/doi/epdf/10.1080/15685551.2024.2449442?src=getftr&utm_source=scopus&getft_integrator=scopus: Unpad Researchers Scale Up Biocompatible PDMS Synthesis for Improved Eye Treatments