Researchers from Universitas Padjadjaran have pioneered a novel biosensing platform for rapid SARS-CoV-2 detection using IgY antibodies conjugated to gold nanoparticles (AuNPs). The team synthesized AuNPs of various sizes via the Turkevich-Seed Growth method, enabling controlled tuning of nanoparticle size in a single reaction using non-toxic materials. These AuNPs were then passively conjugated to chicken-derived anti-N-SARS-CoV-2 IgY antibodies. Characterization using spectrophotometry and particle-size analysis revealed that 63.9 nm particles offered optimal performance, demonstrating excellent stability over nearly one year when stored at 4 °C in the dark, and robust response in half-strip spot tests.

This biosensor advances several key Sustainable Development Goals (SDGs):

SDG 3 (Good Health and Well-Being) — by facilitating accessible, rapid, and equipment-free COVID-19 detection, enhancing public health response capabilities.

SDG 9 (Industry, Innovation and Infrastructure) — through deploying innovative, low-cost nanotechnology suitable for decentralized diagnostics.

SDG 12 (Responsible Consumption and Production) — by leveraging stable, locally producible IgY antibodies and environmentally benign synthesis methods to reduce reliance on costly commercial reagents and complex manufacturing workflows.