A pioneering study led by Diba G. Auliya—affiliated with the Graduate School, Universitas Padjadjaran—has successfully synthesized polymethylhydrosiloxane (PMHS) as a promising alternative to traditional polydimethylsiloxane (PDMS) for vitreous humour substitution. The team explored solvent variation (basic diethyl ether vs. acidic dichloromethane) and controlled condensation temperatures to accelerate polymerization, producing PMHS with both low and medium viscosities. Physical characterizations confirmed the materials’ transparency (~100%), refractive indices in the appropriate range, surface tension values around 20–21 mN/m, and functional group profiles typical of PMHS. Importantly, in vitro HET-CAM toxicity tests indicated no irritant effects, underscoring the polymer’s biocompatibility. This development contributes meaningfully to several Sustainable Development Goals. It advances SDG 3 (Good Health and Well-Being) by offering safer, non-toxic alternatives for ocular surgery materials; supports SDG 9 (Industry, Innovation, and Infrastructure) through novel polymer technology; and aligns with SDG 12 (Responsible Consumption and Production) by facilitating scalable manufacturing of transparent and compatible medical-grade polymers. The research highlights how local scientific innovation can address critical health needs with sustainable, high-performance biomaterials.